Nazopam Nasal Spray(Diazepam)
Therapeutic Group: Benzodiazepines
Presentation
Nazopam™ Nasal Spray: Each actuation delivers Diazepam BP 5 mg.
Description
Diazepam is a benzodiazepine derivative and is a safe tranquilizer with anxiolytic, anticonvulsant, and central muscle relaxant actions. Diazepam attaches to the specific site on the GABA receptor and potentiates the effect of GABA, which acts by opening chloride ion channels into cells.
Indications
Diazepam nasal spray is indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient’s usual seizure pattern in patients with epilepsy 6 years of age and older.
Dosage & Administration
Nasal spray: The recommended dose of Diazepam nasal spray is 0.2 mg/kg or 0.3 mg/kg, depending on the patient’s age and weight.
Table 1: Recommended Dosage for Adults and Pediatric Patients 6 Years of Age and Older
A second dose, when required, may be administered after at least 4 hours after the initial dose. Do not use more than 2 doses to treat a single episode. It is recommended that Diazepam nasal spray be used to treat no more than one episode every five days and no more than five episodes per month.
Instructions for using Nazopam (Diazepam) nasal spray:
- Family members, care partners, and others can promptly administer nasal spray when need it most.
- If a person appears to be having a seizure, lay them either on their side or back.
- Ways of administering various doses: If giving the 5 mg-One spray in one nostril; If giving the 10 mg-One spray in one nostril & one spray in the other nostril; If giving the 15 mg dose-Two sprays in one nostril & one spray in the other nostril; If giving the 20 mg dose-Two sprays in one nostril & two sprays in the other nostril.
Precautions
May cause an increased CNS-depressant effect when used with alcohol or other CNS depressants.Antiepileptic drugs increase the risk of suicidal ideation and behavior.
Commercial Pack
Nazopam™ nasal spray: Each bottle contains Diazepam solution for 50 metered spray.