Winclas Cream(Clascoterone)
Therapeutic Group: Acne Treatment Preparations
Presentation
Winclas Cream: Each gram cream contains Clascoterone INN 10 mg.
Description
Topical Clascoterone (Cortexolone 17?-propionate) is a novel antagonist of androgen receptors in the skin. Within the skin, it binds to androgen receptors with high affinity. By competing with androgens for binding to androgen receptors, Clascolerane works by blocking the androgen receptor signalling cascades that promotes acne pathogenesis such as sebaceous gland proliferation, excess sebum production and inflammatory pathways.
Indications
Clascoterone cream is indicated for the topical treatment of acne vulgaris in patients of 12 years of age and older.
Dosage & Administration
Clean the affected area gently then apply a thin uniform layer of Clascoterone cream twice per day in the morning and evening to the affected area. Avoid accidental transfer of Clascoterone cream into eyes, mouth or other mucous membranes. If contact with mucous membranes occurs, this should be rinsed thoroughly with water. Or, as directed by the physician.
Side Effects
Most common adverse reactions occurring in between 7% to 12% of patients are erythema/ reddening, pruritus and scaling/ dryness. Additionally more than 3% of patients may suffer from edema, stinging and burning.
Precautions
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Use in Pregnancy & Lactation
There is no available data on the use of Clascoterone cream in pregnant women to evaluate a drug associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes.
There is no data regarding the presence of Clascoterone or its metabolite in human milk or the effects on milk production and breastfed infant.
Drug Interaction
No clinical study evaluating the drug interaction of Clascoterone cream has been conducted.
Commercial Pack
Winclas Cream: Each tube contains 10 gm cream.