

Each film coated tablet contains Secnidazole INN 1 gm.

Secnidazole exhibits activity against anaerobic protozoa Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis.
Secnidazole is rapidly absorbed following oral administration. The maximum serum level is obtained after 3 hours following oral administration of 2 gm Secnidazole.
The plasma elimination half life is about 20 hours. The majority of Secnidazole is eliminated via urine (50% of the ingested dose is excreted within 120 hours).

-Hepatic Amoebiasis
-Urethritis and Vaginitis due to Trichomonas vaginalis
-Giardiasis

Amoebiasis:
-Acute intestinal amoebiasis:
Adults: 2 gm single dose (2x1 gm tablet), taken preferably just before meal.
Children: 30 mg/kg single dose, taken preferably just before meal.
-Asymptomatic amoebiasis (minute & cystic form):
Adults: 2 gm once daily (2x1 gm tablet) for only 3 days, taken preferably just before meal.
Children: 30 mg/kg once daily for only 3 days, taken preferably just before meal.
Hepatic amoebiasis:
Adults: 1.50 gm/day, in a single or divided dose, just before meal for 5 days.
Children: 30 mg/kg/day, in a single or divided dose, just before mal for 5 days.
N.B.: Evacuation of pus must be performed simultaneously with Secnidazole treatment at the suppurative stage of hepatic amoebiasis.
Giardiasis:
Adults: 2 gm single dose (2x1 gm tablet), taken preferably just before meal.
Children: 35-50 mg/kg single dose, taken preferably just before meal.
Trichomoniasis:
Adults: 2 gm single dose (2x1 gm tablet), taken preferably just before meal.
Children: 30 mg/kg single dose, taken preferably just before meal.
The partner should also receive the same treatment concomitantly.

The following side-effects may be observed with Secnidazole as with all nitroimidazole derivatives & are rarely serious
Most frequent side-effects: Gastrointestinal disturbances, nausea, epigastric pain, metallic taste, glossitis, and stomatitis.
Occasional side-effects: Urticaria, moderate leukopenia which is reversible on treatment discontinuation.
Rare side-effects: Vertigo, ataxia and motor incoordination, paresthesia, and peripheral neuropathy.
With Secnidazole, gastrointestinal disorders e.g, nausea, vomiting, epigastric pain, etc. have been reported in very rare cases.



