Sudokof(Dextromethorphan, Pseudoephedrine & Triprolidine)
Therapeutic Group: Respiratory
Presentation
Sudokof Antitussive Syrup: Each 5 ml syrup contains Dextromethorphan HBr BP 20 mg, Phenylephrine HCl BP 10 mg & Triprolidine HCl BP 2.5 mg .
Description
Sudocof syrup is a mixture of antitussive, decongestant and antihistamine agent.
Dextromethorphan is used to suppress dry cough. Dextromethorphan is safe, effective and non-narcotic antitussive. It blocks the cough reflex in situations where the dry cough serves no purpose. It does so by calming the cough centre of the brain that governs the coughing reflex. Dextromethorphan does not induce tolerance, and has no potential for addiction like opiates.
Pseudoephedrine acts by stimulating alpha-adrenergic receptors. Pseudoephedrine acts on receptors in the muscles of the blood vessel walls, causing them to contract. This results in narrowing of the blood vessels and decreased blood flow in the lining of the nose and sinuses. Thus fluid congestion in the nose and sinuses is reduced.
Triprolidine is a strong antihistamine, which acts on histamine (H1) receptors. Antihistamines block the action of histamine, preventing dilatation of blood vessels, reducing redness and swelling. It may cause mild drowsiness.
Indications
Sudocof, the combination of Triprolidine, Pseudoephedrine and Dextromethorphan is used to relieve the symptoms of colds and flu, runny nose, nasal congestion and cough, where these are associated with dry cough.
Dosage & Administration
*Adults and Children over 12 years-1 teaspoonful (5 ml) 4 timesin a day
*6-12 years of age-½ teaspoonful (2.5 ml) 4 times
in a day
Side Effects
Few side-effects to be associated with this medicine are known. Because a side-effect is stated here, it does not mean that all people using this medicine will experience that or any side-effect. Rash, difficulty in passing urine (urinary retention), disturbed sleep, drowsiness, disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain, hallucinations, tachycardia, dry mouth, nose and throat are occasionally reported.
Precautions
The combination preparation may cause drowsiness and impair performance in tests of auditory vigilance. It may also impair the patients' ability to drive and also to use machineries. Although there are no objective data, users of this syrup should avoid the concomitant use of alcohol or other centrally acting sedatives. Although pseudoephedrine has virtually no blood pressure effect in patients with normal blood pressure, this combination should be used with caution in patients taking antihypertensive agents, tricyclic antidepressants or other sympathomimetic agents such as decongestant, appetite suppressants and amphetamine like psychostimulants. As with other sympathomimetic agents caution should be excercised in patients with hypertension, heart disease, diabetes, hyperthyroidism, elevated intraocular pressure and prostatic enlargement. This combination should not be used for persistent or chronic cough that occurs with smoking, asthma, or emphysema or where cough is accompanied by excessive secretion unless directed by a physician
Use in Pregnancy & Lactation
Pregnancy: There is no information regarding safety of this medicine in pregnancy. So it must be consulted with doctor before using in pregnancy.
Lactation: The effect of this medicine on the breastfed baby is unknown; therefore this medicine should be used with caution in breastfeeding mothers
Storage
Do not store above 300 C. Keep away from light and out of the reach of children.
Commercial Pack
Sudokof Antitussive Syrup: Each box contains an amber color PET bottle of 100 ml syrup and a measuring cup.