Metoprolol tartrate BP, is a selective �1- adrenoreceptor blocking agent. Metoprolol tartrate is (�)-1- (isopropylamino)-3-[p-(2-methoxyethyl)phenoxy]-2-propanol L-(+)-tartrate (2:1) salt. It is a white, practically odorless, crystalline powder with a molecular weight of 684.82. It is very soluble in water;freely soluble in methylene chloride, in chloroform, and in alcohol, slightly soluble in acetone; and insoluble in ether.

- Hypertension

- Angina Pectoris

- Myocardial Infarction

- Arrhythmias

- Hyperthyroidism

- Migraine Prophylaxis

Hypertension: initially 100mg daily, maintenance 100-200mg daily in 1-2 divided doses
Angina Pectoris: 50-100mg 2-3 times daily.
Myocardial Infarction: After early intravenous treatment for 48 hours, patients should receive a maintenance dose of 100mg twice daily.
Arrhythmias: usually 50mg 2-3 times daily; up to 300mg daily in divided doses if necessary.
Hyperthyroidism: (adjunct), 50mg 4 times daily
Migraine Prophylaxis: 100-200mg daily in divided doses.

Bradycardia, Heart failure, hypotension, Conduction disorder, Bronchospasm, Peripheral vasoconstriction, Gastrointestinal disturbances, Fatigue, Sleep disturbance, Rare reports of rashes and dry eyes, Sexual dysfunction, and Exacerbation of psoriasis.

Gereral: Metoprolol should be used with caution in patients with impaired hepatic function.
Information for Patients: Patients should be advised to take Metoprolol regularly and continuously, as directed, with or immediately following meals. If a dose missed, the patient should take only the next scheduled dose (without doubling it). Patient should not discontinue Metoprolol without consulting the physician. Patients should be advised to
avoid operating automobiles and machinery or engaging in other tasks requiring alertness until the
patient's response to therapy with Metoprolol has been determined.
contact the physician if any difficulty in breathing occurs.
inform the physician or dentist before any type of surgery that he or she is taking Metoprolol.

Hypertension and Angina: Metoprolol is contraindicated in sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure.

Myocardial Infarction: Metoprolol is contraindicated in patients with a heart rate<45 beats/min; second and third-degree heart block; significant first-degree heart block; systolic blood pressure <100 mmHg; or moderate-to-severe cardiac failure.

Pregnancy category C. There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed.
Metoprolol is excreted in breast milk in a very small quantity. An infant consuming 1 liter of breast milk daily would receive a dose of less than 1mg of the drug. Caution should be exercised when Metoprolol is administered to a nursing woman.

Pediatric use
Safety and effectiveness in pediatric patients have not been established.

Presonil Tablet: Each box contains 10 blister strips of 10's tablets