Each 5 ml ampoule contains Dopamine Hydrochloride BP 200 mg.
Dopamine Hydrochloride Injection BP is a clear and colorless solution for intravenous infusion after dilution.
Dopamine hydrochloride can stimulate alpha, beta and dopamine receptors. At infusion rates of 0.5 to 2 micrograms/kg/min, dopamine receptors are selectively activated and blood pressure either does not change or decrease slightly. The most important effects are renal and mesenteric vasodilatation. Renal plasma flow, glomerular filtration rate and sodium excretion usually increase. At infusion rates of 2 to 10 micrograms/kg/min, beta1-receptors are activated and cardiac output and systolic blood pressure increase.
Myomine is recommended for the correction of haemodynamic imbalance present in-
• Acute hypotension or shock associated with myocardial infarction, endotoxic septicaemia, trauma and renal failure.
• As an adjunct after open heart surgery, where there is persistent hypotension after correction of hypovolaemia.
• In chronic cardiac decompensation as in congestive failure.
Dopamine is a potent drug. It must be diluted before administration.
Dilution: Aseptically transfer Sterile Dopamine Concentrate into the intravenous solution as per the table below:
Strength (milligrams/5 ml) | Volume (ml) | Intravenous solution volume (ml) | Final concentration (micrograms/ml) |
---|---|---|---|
200 | 5 | 250 | 800 |
200 | 5 | 500 | 400 |
200 | 10 (2 ampoules) | 250 | 1600 |
200 | 10 (4 ampoules) | 500 | 1600 |
Strength (milligrams/5 ml) | Volume (ml) | Intravenous solution volume (ml) | Final concentration (micrograms/ml) |
---|---|---|---|
200 | 10 (2 ampoules) | 250 | 1600 |
200 | 10 (4 ampoules) | 500 | 1600 |
N/A
Do not add Dopamine to any alkaline diluent solution, since the drug is inactivated in alkaline solution. Patients who have been treated with monoamine oxidase (MAO) inhibitors prior to the administration of dopamine will require substantially reduced dosage. Hypovolaemia should be fully corrected prior to treatment with dopamine with a suitable plasma expander or whole blood or plasma.
Pregnancy: It is not known whether dopamine crosses the placental barrier. The benefits of using this product should be weighed against the possible risks to the foetus.
Lactation: It is not recommended for breast-feeding mothers unless the expected benefits outweigh any potential risks.
Excessive elevation of blood pressure could be expected from accidental overdose. In case of accidental overdose the rate of administration should be reduced or the infusion discontinued temporarily until the patient's condition stabilizes.
Store below 30 °C and protect from light.
Myomine : Each commercial box contains 5 ampoules of 5 ml solution for injection.