Lamivir
Lamivudine 100 mg tablet

Presentation
Each film coated Lamivir tablet contains Lamivudine INN 100 mg.

Description
Lamivudine is a synthetic nucleoside analogue with activity against Hepatitis B Virus (HBV) and Human Immunodeficiency Virus (HIV).

Indications
Lamivir is indicated for the treatment of chronic hepatitis B associated with evidence of hepatitis B viral replication and active liver inflammation.

Dosage and Administration
The recommended oral dose of Lamivudine for the treatment of chronic hepatitis B in adults is 100 mg once daily. Treatment should be continued if there is no loss of efficacy and until adequate seroconversion is achieved.

Side Effects
Nausea, vomiting, diarrhoea, abdominal pain, cough, headache, insomnia, malaise, fever, rash, alopecia, muscle disorders, nasal symptoms, peripheral neuropathy may occur. Sometimes neutropenia and anemia; thrombocytopenia; lactic acidosis, raised liver enzymes and serum amylase have been reported.

Contraindications
Lamivudine is contraindicated in patients with hypersensitivity to any of the components of the product.

Precautions
Patients should be assessed before giving treatment with Lamivudine. Safety and efficacy of Lamivudine have not been established in patients with decompensated liver disease, pediatric patients, patients dually infected with Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV), hepatitis delta. Reduction in dosage is recommended for patients with impaired renal function.

Use in Pregnancy and Lactation
There are no adequate and well controlled studies in pregnant woman. Lamivudine should be used in pregnancy if the potential benefits outweigh the risks. Mother should be instructed not to breastfeed if they are receiving Lamivudine.

Commercial pack
Lamivir : Each box contains 2 blister strips of 10 tablets.