Intasone Cream
Hydrocortisone Acetate 1%

Presentation
Intasone Cream : Each gram cream contains Hydrocortisone Acetate BP 10 mg.

Description
Intasone (Hydrocortisone) cream is primarily effective because of its anti-inflammatory, anti-pruritic and vasoconstrictive action. Hydrocortisone is the principal naturally occurring glucocorticoid in humans. In Pharmaceutical doses its main action is to reduce the response of the skin to injury (i.e. anti-inflammatory action). It also has antimitotic actions.
The anti-inflammatory activity of Hydrocortisone is thought to be mediated by the reduction in formation, release and action of the various vasoactive chemicals released during inflammation- kinins, histamine, lysosomal enzymes, prostaglandins.

Indications
1. Primary irritant dermatitis
2. Contact allergic dermatitis
3. Eczema - atopic, infantile, discoid, stasis
4. Seborrheic dermatitis
5. Lichen simplex and pruritus ani
6. Flexural psoriasis
7. Others - rashes, insect bites, poison ivy, allergies and other irritations

Dosage and Administration
Apply to the affected area as thin film 3 to 4 times daily depending on the severity of the condition.

Side effects
This medication may cause burning, stinging, itching or redness when first applied to the skin. This should disappear in a few days as body adjusts to the medication. Very few common side effects: unusual weakness, weight loss, nausea, vomiting, fainting, and dizziness.

Precautions
This medication should preferably be not used at the area of injuries, surgeries and near the eyes with glaucoma.

Contraindications
A history of hypersensitivity to Hydrocortisone Acetate or any of the components.
Ulcers (delayed wound healing).
Infections - bacterial, viral, fungal.

Use in pregnancy and lactation
There are no adequate and well controlled studies in pregnant women. Hydrocortisone Acetate should only be used during pregnancy if the potential benefit justifies the risk to the fetus. It should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.

The use of topical corticosteroids during lactation is unlikely to present a hazard to infants being breast-fed.

Drug interaction
No significant drug interactions have been described with Hydrocortisone Acetate.

Overdosage
Acute overdose is very unlikely to occur. However, if signs and symptoms of systemic overdosage occur, the drug should be discontinued.

Storage
Store at room temperature. Away from sunlight. Avoid freezing.

Commercial pack
Intasone Cream: Tube containing 10 gm of Hydrocortisone Acetate cream.