Indapril Tablet
Indapamide and Perindopril Erbumine

Presentation
Indapril   2: Each tablet contains 0.625 mg of Indapamide and 2 mg of Perindopril Erbumine.
Indapril   4: Each tablet contains 1.25 mg of Indapamide and 4 mg of Perindopril Erbumine.
 
Description
Indapril, a fixed combination of an ACE inhibitor and a thiazide-like diuretic, leads to additive synergy of the antihypertensive effects of the two constituents. Its pharmacological properties are derived from those of each of the components taken separately. In addition to those due to the additive synergistic action of the two constituents, when combined, it shows beneficial effects on vascular endothelium, arteriolocapillary microcirculation, and the target organs of hypertension.
 
Indication & Uses
Essential hypertension.
 
Dosage and Administration
One tablet daily, preferably to be taken in the morning and before a meal.
Elderly patients: Normal dosage.
Renal failure: Creatinine clearance (CrCl) >30 ml/min: no dosage modification.
CrCl <30 ml/min: treatment contraindicated.
 
Side Effects
Asthenia, dizziness, headache, mood swings and/or sleep disturbances, cramps, hypotension, allergic reactions, skin rashes, gastrointestinal disorders, dry cough, dry mouth, risk of dehydration in the elderly and in patients suffering from heart failure; changes in blood test results may occur.
 
Precautions
Disorders of electrolyte balance, diabetes, gout, hypotension, or strict sodium-free diets, heart or renal failure, atherosclerosis, renal artery stenosis, elderly.
 
Contraindications
Absolute: Known allergy to perindopril Erbumine, indapamide, or sulfonamides; history of Quincke's edema linked to previous ACE inhibitor therapy; severe renal failure; serious liver disorder; hypokalemia; pregnancy; lactation.
Relative: Combination therapy with lithium, potassium salts, potassium-sparing diuretics, and certain medicines which can cause heart rhythm disorders.
 
Drug Interactions
Not recommended: Combinations with lithium, potassium-sparing diuretics, potassium (salts), antiarrhythmic drugs which cause torsade de pointes, anesthetic drugs, cytostatic or immunosuppressive agents.
 
Commercial Pack
Indapril   2: Each box contains 3 blister strips of 10 tablets.
Indapril   4: Each box contains 2 blister strips of 10 tablets.