Econate Cream
Econazole Nitrate

Presentation
Econate Cream: Each gram cream contains Econazole Nitrate BP 10 mg.

Description
Econazole nitrate is a broad spectrum antifungal agent. The range of action of Econazole covers all dermatomycoses caused by the following pathogens :
Deramtophytes, such as Trichophyton, Epidermophyton, Microsporum, Cladosporium and others.
Yeasts, such as Candida, Cryptococcus neoformans, Torulopsis, Rhodotorula and others.
Moulds and other Fungi, such as Scopulariopsis brevicaulis, Aspergillus flavus, Histoplasma capsulatam, Blastomyces dermatitidis, and others. As well as Malassezia furfur and Nocardia minutissima.
Moreover, it has antibacterial effect on Gram-positive cocci and bacilli, including Streptococcus pyogens and Staphylococcus aureus.
It is also effective against Trichomonus vaginalis.

Indications
All fungal skin infections due to dermatophytes, yeasts, moulds and other fungi. These include Vulvo-vaginal candidiasis, Candidial napkin rash, and other candidial infection, Ringworm (tinea) infections, Athlete's foot paronychia, Pityriasis versicolor and Balanitis. For the treatment of onychomycoses, local therapy with Econazole cream, combined with an oral antimycotic, is recommended.

Dosage and Administration
Econazole cream is applied to the affected skin areas once or twice daily, in the morning and/or in the evening and gently rubbed in with the clean finger. For mycoses of the hands, application is recommended following each washing of the hands. For the treatment of onychomycoses, occlusive dressings are recommended. In order to prevent relapse, treatment should be continued for 2 weeks after clinical cure.

Side effects
Rarely, transient local mild irritation, itching & redness may occur immediately after application. Econazole has minimal allergic effect. It is well tolerated, even by delicate skin. Local irritations are not likely to occur, except in rare cases, e.g., in eczematous skin areas. In such cases, anti-eczematous treatment is recommended for several days before therapy with Econazole is initiated.

Contraindications
There is no information about the contraindication of Econazole.

Precautions
Hypersensitivity has rarely been recorded. If something like this occur, administration of the product should be discontinued. The infected area should be kept clean and dry during treatment.

Use in pregnancy and lactation
During pregnancy: There is no information of any abnormality or adverse event in neonates while Econazole cream had been used during pregnancy.
During lactation: As the systemic absorption of Econazole Nitrate cream is extremely low after topical use, excretion in breastmilk is likely to be negligible. So, it can be used topically during lactation if needed.

Overdosage
Econazole cream is intended for topical use. If accidental ingestion of large quantities of the product occurs, an appropriate method of gastric emptying may be used if considered desirable.

Commercial Pack
Econate Cream: Tube containing 10 gm of Econazole Nitrate cream.