Topicacin
Capsaicin Cream

Presentation
Topicacin 0.025% w/w Cream: Each gram cream contains Capsaicin USP 0.25 mg.

Description
Topical Capsaicin has been used to treat different types of pain. Capsaicin renders skin insensitive to pain by depleting and preventing reaccumulation of substance P in peripheral sensory neurons. Substance P is the principal chemomediator of pain impulses from the periphery to the Central Nervous System.

Indications and Uses
Rheumatoid arthritis
Osteoarthritis
Pain due to diabetic neuropathy
Joint pain
Post-herpetic neuralgia
Post-surgical neuropathic pain
Nerve Pain
Back pain
Muscle pain
Fibromyalgia
Bursitis
Pruritis (itching)

Contraindications
Capsaicin cream is contraindicated for use on broken or irritated skin or known hypersensitivity to this medication.

Dosage And Administration
Persons 18 years of age and older apply a thin film of Capsaicin cream to affected area 3 to 4 times daily. A burning sensation may occur upon application, but generally disappears with regular use. Application schedules of 3 to 4 times a day for 2 weeks provides optimum pain relief.

Precautions
Capsaicin cream should not be applied to broken or irritated skin. Applied area should not be tightly bandaged. Do not get on mucous membranes and into eyes or on contact lenses. If this occurs, rinse the affected area thoroughly with water. Do not apply the cream on the heat treated area as this may increase the burning sensation. In case of accidental ingestion, seek physician advice immediately.

Side Effects
Capsaicin may cause transient burning on application. This burning is observed more frequently when the application schedules are more than 3-4 times daily. The burning can be enhanced if too much cream is used and if it is applied just before or after a bath or shower.

Use in pregnancy & lactation
The safety of Capsaicin during pregnancy or lactation has not been established in either humans or animals.

Overdosage
Sufficient information on overdose of Capsaicin is not available.

Storage
Store at 15-30 °C

Commercial Pack
Topicacin 0.025% w/w Cream: Each tube contains 20 gm cream.;