Dilast
Torasemide tablet

Presentation
Dilast 2.5: Each tablet contains Torasemide INN 2.5 mg.
Dilast 5: Each tablet contains Torasemide INN 5 mg.

Description
Torasemide is a sulfonamide - type, loop diuretic. It acts on the lumen of thick ascending limb of loop of Henle, and thus reducing NaCl reabsorption. This leads to remove excess water from the body. It does not significantly alter glomerular filtration rate, renal plasma flow, or acid-base balance. In low doses, it is also used as an antihypertensive agent.

Indications and Uses
Torasemide is indicated for-
1.The management of edema of cardiac, renal and hepatic origin.
2.The management of hypertension, as a sole therapeutic agent or in combination with
3.Other classes of antihypertensive agents.

Dosage and Administration
Adults
Edema: The usual oral dose is 5 mg once daily, preferably in the morning. If necessary, the dose can be increased stepwise up to 20 mg once daily. The usual maximum dose is 40 mg daily. Dosage can be taken without regard to meal.
Essential hypertension: An oral dose of 2.5 mg once daily is recommended. If necessary, the dose can be increased to 5 mg once daily.

Contraindications
Torasemide is contraindicated in patients with known hypersensitivity to torasemide and other sulfonyl ureas. It is also contraindicated in patients who are anuric.

Precautions
Precautions should be taken while torasemide is administered in the conditions like diabetes, gout, hypotension and liver failure.

Side-effects
Usually torasemide is well tolerated. However, a few side effects like dry mouth, dizziness, tiredness, skin rash, diarrhea, constipation, nausea, vomiting, orthostatic hypotention and muscle cramp may occur. All side effects usually are mild and transient.

Use in pregnancy & lactation
Pregnancy: Adequate and well - controlled studies of torasemide have not been carried out in pregnant woman. Because animal reproduction studies are not always predictive of human response, torasemide can be used during pregnancy only if clearly needed.
Nursing Mother: It is not known whether torasemide is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when torasemide is administered to a nursing mother.

Use in children
Safety and efficacy of torasemide in children have not been established.

Drug Interactions
ACE inhibitors: Potentiation of hypotension may occur.
Aminoglycosides:Torasemide may increase the ototoxicity of aminoglycosides.
Corticosteroides: Increment of risk of hypokalemia.

Overdosage
There is no human experience of overdoses of torasemide, but the signs and symptoms of overdosage can be anticipated to be those of excessive pharmacological effect: dehydration, hypovolemia, hypotension and hypokalemia. Treatment of overdose should consist of fluid and electrolyte supplement.

Commercial Pack
Dilast 2.5 Tablet: Each box contains 10 blister strips of 10 tablets.
Dilast 5 Tablet: Each box contains 10 blister strips of 10 tablets.