Consucon MR Tablet
Consucon  MR Gliclazide Modified Release Tablet

Presentation
Consucon  MR Tablet : Each modified release tablet contains Gliclazide BP 30 mg.
 
Description
Consucon MR is a second generation sulphonylurea drug that has hypoglycemic and potentially useful hemobiological properties. It stimulates the release of insulin from pancreatic beta cells by facilitating calcium ion transport across the beta cell membranes and decrease hepatic glucose output.
 
Indications
Consucon MR is indicated for the treatment of maturity onset diabetes mellitus (Type-2 DM) patients who require oral hypoglycemic drug.
 
Dosage & Administration
The usual daily dosage is 1 to 4 tablets per day as a single dose. It is recommended that the drug should be taken at breakfast time. It is preferable to take this drug before breakfast in order to avoid or to minimize the possible onset of digestive disorders.
 
Contraindications
Gliclazide should not be used in -
Type-1 diabetes
Diabetic keto-acidosis
Diabetic patients undergoing surgery, after severe injury or during infection
Patients having hypersensitivity for sulfonylurea group of drugs
Pregnant women and breast feeding mother
Severe renal or hepatic insufficiency
 
Precautions
Gliclazide should be used carefully in patients with hepatic impairment. If there is definite hepatic disease then Gliclazide should not be used. Gliclazide can be used safely in patients with renal insufficiency as it is extensively metabolized. Gliclazide has less sudden hypoglycemic episode than other sulfonylurea group of drugs.
 
Use in Pregnancy & Lactation
Pregnant Women: Gliclazide should not be used in pregnant women although animal studies of Gliclazide have not shown any teratogenic effect.
Nursing Mothers: This drug is contraindicated when breast feeding.
 
Side-effects
There may be hypoglycemia in concurrent conditions such as hepatic and renal disease, malnutrition, alcohol intoxication. Sometimes headache, gastrointestinal upsets, nausea, dizziness, skin reactions including rash, pruritis, erythema may occur.
 
Drug interactions
The hypoglycemic effects of Gliclazide may be increased by Aspirin, NSAIDs, Phenylbutazone, Clofibrate, Sulfonamide, Cemetidine, Imidazole antifungal agents and Monoamino Oxidase Inhibitors. The hypoglycemic effect of Gliclazide sometimes may be reduced by Rifampin, Barbiturates, Phenytoin, Thiazide diuretics, Diazoxide, Glucocorticoids, Estrogens, Sympathomymetic drugs and occasionally alcohol.
 
Over dosage
In accidental overdose, at first gastric lavage should be done and at the same time the hypoglycemia should be corrected. In severe cases I/V infusion of 5% glucose should be started immediately with frequent monitoring of blood glucose and potassium level.
 
Commercial pack
Consucon  MR Tablet : Each box contains 3 blister strips of 10 tablets.