Presentation
Adora 500 Capsule: Each capsule contains Cefadroxil Monohydrate USP equivalent to Cefadroxil 500 mg.
Adora Powder for Suspension: When reconstituted each 5 ml of suspension contains Cefadroxil Monohydrate USP equivalent to Cefadroxil 125 mg.
Adora Powder for Paediatric Drops: When reconstituted each 1.25 ml contains Cefadroxil Monohydrate USP equivalent to Cefadroxil 125 mg.
Description
Adora (Cefadroxil Monohydrate) is an acid-stable semi-synthetic oral antibiotic in the cephalosporin family of drugs. Cefadroxil acts by preventing bacteria from forming protective cell wall necessary for survival. It has superior pharmacokinetic profile over all first generation cephalosporins.
Indications
Adora (Cefadroxil Monohydrate) is indicated for the treatment of patients with infection caused by susceptible strains of the designated organisms in the following diseases:
Upper respiratory tract infections caused by Streptococcus pyogenes (Group A beta-hemolytic Streptococci) and Streptococcus pneumoniae.
Urinary tract infections caused by E. coli, Proteus mirabilis, and Klebsiella species.
Skin and soft tissue infections caused by Staphylococci (including penicillinase producing strains) and Streptococci.
Dosage & Administration
The bioavailability and consequent chemotherapeutic effects of Cefadroxil are unaffected by foods. It may, therefore, be taken with meals or on an empty stomach. Administration with food may be helpful in diminishing potential gastrointestinal complaints occasionally associated with oral cephalosporin therapy.
Indications Adults Children
Upper respiratory tract1 gm per day in single (q.d.) or 30 mg / kg/ day in a single or
infections divided doses (b.i.d.) for 10 daysin equally divided doses every
12 hours for 10 days
Urinary Tract Infections For uncomplicated UTIs 30 mg / kg/ day in equally
1 or 2 gm per day in single (q.d.) or divided doses every 12 hours
divided doses (b.i.d.)
For all other UTIs
2 gm per day in divided doses (b.i.d.)
Skin & soft tissue1 gm per day in single (q.d.) or 30 mg / kg/ day in equally
infections divided doses (b.i.d.)divided doses every 12 hours
Patients with renal impairment
In patients with renal impairment , the dosage of Cefadroxil Monohydrate should be adjusted according to creatinine clearance rates to prevent drug accumulation. The following schedule is suggested. In adults the initial dose is 1000 mg of Cefadroxil Monohydrate and the maintenance dose (based on the creatinine clearance rate [ml/min/1.73 m2]) is 500 mg at the time intervals listed bellow:
Creatinine Clearance Dosage Interval
0-10 ml/min 36 hours
10-25 ml/min 24 hours
25-50 ml/min 12 hours
>50 ml/minNo adjustment
Cefadroxil Monohydrate can be removed from the body by hemodialysis.
Side Effects
Side-effects
Generally cefadroxil is well tolerated. However, the most commonly reported side effects are gastrointestinal disturbances and hypersensitivity phenomena. Side effects including nausea, vomiting, diarrhoea, dyspepsia, abdominal discomfort, fever, dizziness, headache, arthralgia may also occur.
Use in pregnency
Cefadroxil (Adora) is widely used as a first-line oral antibiotic for the treatment of uncomplicated urinary tract infections in pregnant women.
Contraindications
Cefadroxil is contraindicated in patients with a history of hypersensitivity to any of the ingredients.
Drug interactions
There is no known clinically important drug interactions with Cefadroxil.
Overdosage
If amounts >250 mg/kg is ingested, gastric lavage or simulation of vomiting is appropriate.
Direction for Reconstitution of suspension
- For 100 ml suspension: Add 65 ml (13 measuring spoonful) of boiled and cooled water to the dry mixture in the bottle. For ease of preparation add water to the bottle in two portions. Shake well after each addition until all the powder is in suspension.
- For 60 ml suspension: Add 40 ml (8 measuring spoonful) of boiled and cooled water to the dry mixture in the bottle. For ease of preparation add water to the bottle in two portions. Shake well after each addition until all the powder is in suspension.
- Paediatric Drops: Add 10 ml (2 measuring spoonful) to the bottle and shake vigorously.
Note: Shake both oral suspension and paediatric drops well before each use. Keep the bottle tightly closed. The reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator and unused portion should be discarded after 14 days.
Commercial pack
Adora 500 mg Capsule: Box containing 4 blister strips of 10's capsules.
Adora Powder for Suspension: Bottle containing powder to produce 100 ml suspension when reconstituted.
Adora Powder for Suspension: Bottle containing powder to produce 60 ml suspension when reconstituted.
Adora Powder for Paediatric Drops: Bottle containing powder for preparation of 15 ml suspension.
