Other uses of Erythropoietin

Reduction of Allogeneic Blood Transfusion in Surgery Patients


EPOETIN is indicated for the treatment of anemic patients (hemoglobin > 10 to 13 g/dL) scheduled to undergo elective, noncardiac, nonvascular surgery to reduce the need for allogeneic blood transfusions.18-20 EPOETIN is indicated for patients at high risk for perioperative transfusions with significant, anticipated blood loss. EPOETIN is not indicated for anemic patients who are willing to donate autologous blood (see BOXED WARNINGS and DOSAGE AND ADMINISTRATION).


Treatment of Anemia in Zidovudine-treated HIV-infected Patients

EPOETIN is indicated for the treatment of anemia related to therapy with zidovudine in HIV-infected patients. EPOETIN is indicated to elevate or maintain the red blood cell level (as manifested by the hematocrit or hemoglobin determinations) and to decrease the need for transfusions in these patients.


EPOETIN is not indicated for the treatment of anemia in HIV-infected patients due to other factors such as iron or folate deficiencies, hemolysis, or gastrointestinal bleeding, which should be managed appropriately.


EPOETIN, at a dose of 100 Units/kg TIW, is effective in decreasing the transfusion requirement and increasing the red blood cell level of anemic, HIV-infected patients treated with zidovudine, when the endogenous serum erythropoietin level is 500 mUnits/mL and when patients are receiving a dose of zidovudine 4200 mg/week.

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